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Temodal®
RX Navigator

Interactive visualization of the safety profile of Temodal (temozolomide) based on the official Summary of Product Characteristics (SmPC).

Patient Details

Age (years)

Duration/Cycles

Risk assessment for long-term treatment.

CrCl (mL/min)

Sex: Female Male

Is patient pregnant? Is patient planning pregnancy? Is patient breastfeeding?

Has a female partner of reproductive potential?

Uses effective contraception (condoms)?

Conditions, History, and Risk Factors

Conditions and History

Hypersensitivity to TMZ or DTIC Severe myelosuppression at baseline (listed as contraindication)

Hepatitis B Virus (HBV) Status:

History of severe allergic reactions (to other medications) History of aplastic anemia / pancytopenia History of MDS or AML History of other malignancies (excluding MDS/AML) History of chronic lung disease (fibrosis, COPD) Severe hepatic impairment Mild/moderate hepatic impairment Severe renal impairment (explicitly mentioned) Mild/moderate renal impairment (explicitly mentioned) History of PCP Lactose intolerance / galactosemia / malabsorption

Baseline Blood Counts

Low ANC (< 1.5 x 10⁹/L) at baseline Low platelet count (< 100 x 10⁹/L) at baseline Anemia at baseline

Liver Function (Baseline LFTs)

ALT (U/L)

AST (U/L)

Bilirubin (µmol/L)

Or check: Abnormal baseline LFTs (without values)

Concomitant Therapy and Current Symptoms

Interacting or Concomitant Medications

Valproic Acid Enzyme Inducers (anticonvulsants, etc.) Corticosteroids (dexamethasone, etc.) Other Myelosuppressive Agents

Other Treatment Factors

Concomitant Radiotherapy (especially for GBM)

Current Symptoms (Warning Signs)

Fever or signs of infection Seizures (new / worsening) Confusion / Change in Mental Status Dyspnea (new / worsening)

*according to the official SmPC

Risk Factors

Key Information from SmPC:

Recommendations:

This tool is for informational purposes only. It is not a medical device and is not intended for diagnosis, treatment decisions, or clinical management. The information provided does not replace full review of the official Summary of Product Characteristics (SmPC) for Temodal or the professional judgment of a physician or pharmacist.

Temodal® RX Navigator