Test Scenarios - Saxenda®

Scenario 1: "Safe" Level

Patient Description:

Female, 38 years old.

Anthropometry: Weight 98 kg, height 168 cm (BMI ≈ 34.7 kg/m²).

CrCl: 110 mL/min.

Conditions: None relevant (no checkboxes selected).

Concomitant Medications: None relevant (no checkboxes selected).

Expected Duration: 26 weeks.

Input Data (Example):

  • Age: 38
  • Sex: Female
  • Weight (kg): 98
  • Height (cm): 168
  • CrCl (mL/min): 110
  • Conditions: (none selected)
  • Medications: (none selected)
  • Expected Duration (weeks): 26

Expected Result:

🟢 Safe Level

Verdict: "Specific Risks Not Identified (Refer to General Information)"

Reasons: (list empty)

General Information Block: Visible.

Scenario 2: "Medium Risk" Level

Patient Description:

Adolescent male, 16 years old.

Anthropometry: Weight 105 kg, height 175 cm (BMI ≈ 34.3 kg/m²). (IOTF check for 16 y.o. male: threshold 28.88 kg/m². BMI > threshold - indication met).

CrCl: 120 mL/min.

Conditions: Thyroid disease (checkbox 'thyroid' selected).

Concomitant Medications: None relevant.

Expected Duration: 52 weeks.

Input Data (Example):

  • Age: 16
  • Sex: Male
  • Weight (kg): 105
  • Height (cm): 175
  • CrCl (mL/min): 120
  • Conditions: Thyroid disease
  • Medications: (none selected)
  • Expected Duration (weeks): 52

Expected Result:

🟡 Medium Risk

Verdict: "Medium Risk / Requires Caution & Specific Monitoring"

Reasons:

  • Other thyroid disease: Use with caution. Monitor thyroid symptoms...

General Information Block: Visible (including reminder about efficacy assessment in adolescents).

Scenario 3: "High Risk" Level

Patient Description:

Male, 62 years old.

Anthropometry: Weight 120 kg, height 180 cm (BMI ≈ 37.0 kg/m²).

CrCl: 75 mL/min (Mild renal impairment).

Conditions: Type 2 diabetes mellitus (checkbox 'diabetes_t2' selected), Hypertension (checkbox 'hypertension' selected).

Concomitant Medications: Insulin (checkbox 'insulin' selected), Warfarin (checkbox 'warfarin' selected).

Expected Duration: 24 weeks.

Input Data (Example):

  • Age: 62
  • Sex: Male
  • Weight (kg): 120
  • Height (cm): 180
  • CrCl (mL/min): 75
  • Conditions: Type 2 diabetes mellitus, Hypertension
  • Medications: Insulin, Warfarin
  • Expected Duration (weeks): 24

Expected Result:

🟠 High Risk

Verdict: "High Risk / Requires Special Attention & Monitoring"

Reasons:

  • T2DM + Insulin/Sulphonylurea: risk of hypoglycaemia...
  • Concomitant warfarin/coumarins: risk of INR changes...
  • Mild renal impairment (CrCl 75.0): Use with caution...
  • In hypertension: Monitor BP.

General Information Block: Visible.

Scenario 4: "Contraindicated" (Critical Level)

Patient Description:

Female, 45 years old.

Anthropometry: Weight 110 kg, height 165 cm (BMI ≈ 40.4 kg/m²).

CrCl: 25 mL/min (Severe renal impairment).

Conditions: Planning pregnancy (checkbox 'pregnancy' selected).

Concomitant Medications: Another GLP-1 receptor agonist (e.g., Ozempic) (checkbox 'other_glp1' selected).

Expected Duration: Not applicable.

Input Data (Example):

  • Age: 45
  • Sex: Female
  • Weight (kg): 110
  • Height (cm): 165
  • CrCl (mL/min): 25
  • Conditions: Planning pregnancy
  • Medications: Other GLP-1 receptor agonists
  • Expected Duration (weeks): N/A

Expected Result:

🔴 Contraindicated

Verdict: "Use Contraindicated / Discontinue Immediately"

Reasons:

  • Pregnancy / Planning: absolute contraindication.
  • Severe renal impairment (CrCl < 30): use contraindicated/not recommended...
  • Combination with other GLP-1 RAs: do not use concomitantly.

General Information Block: Not displayed.